前苏联专利SU1099831A3 Fodder additive for ruminant animals

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专利摘要:
1. A particulate rumen-penetrating feed additive for ruminants in which at least one biologically active substance is provided with a coating containing a salt of an aliphatic monocarboxylic acid containing from 14 to 22 carbon atoms or of ricinoleic acid or of a mixture of several such acids, characterised in that it contains - based in each case of the total weight - a) from 30 to 50% by weight of at least one biologically active substance, b) from 10 to 35% by weight of at least one sodium, potassium or calcium salt of an aliphatic C14 -C22 monocarboxylic acid or of ricinoleic acid and c) the balance to 100% by weight, but at least 30% by weight of at least one aliphatic C14 -C22 monocarboxylic acid or ricinoleic acid and/or of a hardened vegetable or animal fat.
公开号:SU1099831A3
申请号:SU813262402
申请日:1981-03-23
公开日:1984-06-23
发明作者:Шпиндлер Манфред；Таннер Херберт
申请人:Дегусса Аг (Фирма)；
IPC主号:

专利说明:

The invention relates to fodder production, in particular, to feed additives for ruminants, and can be used in feeding them to meet the need for biologically active substances. Feed additives for ruminants are known, containing biologically active substances in the form of methionine and its derivatives, which are used in feeding ruminants for balancing the diet from sources of acid AO. However, the supplements are not fully absorbed by the body of the animal, which reduces their nutritional value. Feed additives for ruminant animals are known, containing a biologically active substance, selected from the group including lysine hydrochloride, nicotinic acid amide, methionine or its mixture with feather flour, and a protective coating for the biologically active substance selected from sodium or potassium salt of stearic and palmitic acids 2, the protective coating of the known additive is stable in the stomach, but after passing into the intestines dissolves by exposure and juice of the pancreas gland. However, due to the fact that the dissolution of the coating requires the action of bile and pancreatic juice, the time required for digestion and absorption is significantly reduced. The purpose of the invention is to create conditions for better absorption and digestion of the feed additive containing biologically active substances. This goal is achieved in that in the feed additive for ruminants containing a biologically active substance selected from the group includes a lysine hydrochloride, nicotinic acid amide, methionine or its mixture with feather flour, and a protective coating for the biologically active substance selected from the group including sodium or potassium salt of stearic or palmitic acid, its protective coating additionally contains stearic or palmitic acid or hardened vegetable oil or animal fat with eduyuschem ratio of components, May. %: Biologically active substance selected from the group including lysine hydrochloride, nicotinic acid amide, methionine or its mixture with feather flour 30-50 Sodium or potassium salt of stearic or palmitic acid 10-35 Stearic acid or palatinic acid or. hardened vegetable oil or animal oil 30-60 Coating particles in the proposed additive, unlike the known ones, in which the coating consists only of salts of fatty acids, is already destroyed in the acidic environment of the abomasum, and the biologically active substances are released without bile and pancreatic juice. However, the proposed additives are resistant to the action of environments with the pH of gastric juice and to bacterial destruction in the stomach. They pass through the stomach, the dissolution of their coating begins already in the rennet, as a result of which the time available for digestion and absorption is increased. The proposed feed additive can be obtained by first preparing a homogeneous melt of the components forming a protective coating. Then, in the prepared melt, the biologically active substance or a mixture of biologically active substances is dispersed with stirring, which must be protected. Immediately thereafter, the liquid dispersion is oscillated by vibration at a frequency and squeezed through a die. At the same time, the flow leaving each hole is divided into individual droplets of a certain size, which, after the formation of spherical particles, solidify with a free fall. In this way, spherical particles of any diameter in the range from 50 to 2500 µm and with a narrow spectrum of grain size distribution can be obtained. A particularly important biologically active substance found in the proposed feed additive is 3 methionic acids. Research confirms that among all amino acids, as a rule, methionine is primarily a limiting amino acid for ruminants. In order to increase the growth of wool, methionine is introduced into the fourth section of the sheep's stomach. In the case of oxen, methionine is introduced into the fourth section of the stomach to achieve an increased K1 balance. Studies carried out on cows also confirm that methionine, protected during stomach passage, from which free methionine forms in the abomasum, increases the milk yield, increases the protein and fat content in milk, and increases fertility as an additive to the usual feed. . Other important biologically active compounds are vitamins. For example, a lack of vitamin A in the case of cattle leads to poor appetite and, consequently, to a small increase in weight. As a result of a lack of this vitamin, cows may be healed by premature calving or by the appearance of dead bodies. When medicines are administered through the mouth, the biologically active substance is usually desirable only after the passage of the stomach. In this case, the proposed additive can be successfully applied. Example 1. a) (Experiment for comparison). 70 parts of stearic acid is melted at 80 ° C. 30 parts of methionium are suspended while stirring and the melt is squeezed out by drops through a nozzle, and regular spherical particles with a diameter of 1-2 mm are formed; b) from a mixture of 60 parts of stearic acid and 10 hours of sodium stearate as a result of heating at 80 ° C to obtain a homogeneous melt, in which 30 parts of methionine are mixed in with equal frequency. Particles are produced by analogy with the description in paragraph a. In a similar way, particles are obtained from: c) 30 parts of methionine, 55 parts of stearic acid and 15 hours of stearate; d) 30 parts of methionine, 50 parts of stearic acid and 20 parts of sodium stearate:. 44 e). And parts of methionium, 50 parts of stsg1 rinic acid and 20 parts of potassium stearates; f) 3 () parts of methionine, 45 parts of stearic acid and 25 parts of sodium stearate; g) 30 parts methionine, 35 parts stearic acid and 35 parts sodium stearate. To study the specific and pH-dependent release of the active substance by using different RP values of the gastric juice and rennet juice, the additive was incubated for 2 hours at 37 ° C in 50 ml of the buffer system, which corresponds to the pH value of the stomach medium with constant stirring lineage unit. The buffer system consists of a solution of 74.77 g of potassium dihydrogen phosphate, 103.03 g of sodium hydrogen phosphate and 13.5 g of potassium iodide in 1 liter of water. The pH of the buffer system is 6.5. At the same time, the particles are incubated for 2 hours at 50 ml of the buffer system, which corresponds to the rennet medium in terms of pH. This system consists of a solution of 6.5 iGI 0.2 n. hydrochloric acid and 25.0 ml 0.2 n. solution of potassium chloride in 100 ml of water. The pH of this buffer system is 2.0. Immediately after this, the insoluble particles are separated by filtration, and the solutions are mixed in each case with 100 ml of phosphate buffer solution with a pH of 6.5, and in each case the pH is adjusted to 6.5 Immediately after this, the amount of methionine that passed from the particles into the solution is determined iodometrically. . The results of the dissolution of the additive are presented in table. 1. The product containing 20Z stearate leads to a very effective release of methionine at the rennet pH value, and this occurs without the use of enzymatic activity. A lower or higher amount of stearate leads to a less effective release of methionine during the control for only 2 hours. This effect can also be observed visually: while the additives corresponding to the item do not have an acid buffer after aging.
The changes, supplements corresponding to items id, are destroyed in many places. Additives corresponding to clauses b 5 f and 6 have a slightly softened outer layer.
Example 2. In a similar way, get supplements with a content of methionine 40% based on the weight of the final product. The amount of sodium stearate is 10.15 and 20%. For comparison, the product is prepared and examined without the addition of stearate.
The compositions of the products and the results of the dissolution of methionine are presented in table. 2
A higher content of stearate than described in the example results in a melt having a high viscosity, which makes it difficult to produce even large particles. When a fatty acid is completely replaced with a fatty acid salt, a melt cannot be obtained even when heated to 180 ° C. In addition, this leads to a significantly greater thermal effect on the substance being banned.
Example 3. In order to compare the results of the above described experiment with the results obtained with the use of physiological solutions, the product corresponding to item L, equally for 2 hours, lives at 50 ml of rennet juice. The determination is carried out in a similar manner.
The results of the dissolution of methionine are presented in Table 3.
Example 4. To assess whether a product containing 10% sodium stearate can be obtained from a tb item after a prolonged stay in juice, an increased release of the active substance is observed compared to the product obtained in accordance with paragraph 1a (without stearate, both products are kept in for 16 h at 37 C b juice rennet.
The results of the dissolution of methionine are given in table. four.
Example 5. By analogy with the methods described in examples 1 and 2, a product is obtained consisting of: o) 30% of lysine hydrochloride and 70% of stearic acid; B) 30% from lysine hydrochloride, 50% from stearic acid and 20% from sodium stearate,
After 2 hours at 37 ° C in a buffer with pH of the abomasum, particles are filtered and the solution is examined for lysine content on an LKB 3201 amino acid analyzer with a chromatography column.
The difference in the rates of release of the active substance was established.
Lysine Dissolution Results
shown in Table 5.
Example 6. In accordance with Example 1, supplements are obtained, consisting of: a) 30% nicotinic acid amide and 70% stearic acid; (B) 30% from nicotinic acid amide; 50% from stearic acid and 20% from sodium stearate;
After soaking in abomasum juice
For 2 hours, the filter is filtered and the Kjeldahl method is used to determine the nitrogen content. By comparing the obtained value with the nitrogen content, which is analytically determined prior to the onset of exposure, the degree of release of the active substance is determined,
The results of the nicotinic acid amide dissolution are shown in Table 6.
Example 7. By analogy with the methods described in examples 1 and 2, additives are obtained, in the protecting layer of which hardened soybean oil is contained.
The compositions of the products and the results of experiments carried out by analogy with that described in example 1 are given in table. 7
The results of the nicotinic acid amide dissolution are shown in Table 7.
Example 8. By analogy with the above described method, a product is obtained which is protected by methionine and protein in combination. As a protein, feathers crushed into flour are used.
After the product has been excreted in the stomach and rennet buffets, by analogy with the solution described in Example 1, the solutions are examined using an chromatographic column for the content of amino acids. Along with methionine, only mediums of other amino acids are detected. The results of the dissolution of the protein product are presented in table. eight.
Example 9. a) From a mixture of 60 hours of stearic acid and 10 parts of sodium palmitate is obtained by heating to a homogeneous melt, in which 30 parts of methionine are suspended. The melt is dropped from the nozzle, thus obtaining the same spherical particles with a diameter of 1-2 mm.
Similarly, particles are obtained from:
b) 30 parts of methionine, 50 parts of stearic acid and 20 parts of sodium palmitate;
c) 30 parts of methionine, 50 hours, stearic acid and 20 parts of potassium palmitate;
d) 30 parts of methionine, 35 parts of stearic acid and 35 parts of sodium palmitate;
e) 30 hours, methionine, 60 parts of palmitic acid and 10 hours of sodium stearate;
f) 30 parts of methionine, 50 parts of palmitic acid and 20 parts of sodium stearate;,
g) 30 hours, methionine, 50 parts of palmitic acid and 20 parts of potassium stearate;
h) 30 h, methionine, 35 parts of palmitic acid and 35 parts of sodium stearate.
The results of the dissolution of methionine are given in table. 9.
The results of the dissolution of methionine are given in table. ten.
Example 10. a) From a mixture of 60 h of animal fat (hardened) and 10 hours of sodium palmitate, a uniform melt is obtained by heating to 80 ° C in which methylene is suspended for 30 h. The melt is dropped from the nozzle, thus obtaining the same spherical particles with a diameter of 1-2 mm.
Similarly, receive
particles from:
b) 30 parts of methionine, 50 parts of vegetable fat (hardened) and 10 parts of potassium palmitate;
d) 30 parts of methionine, 50 parts of animal fat (hardened) and 20 parts of potassium palmitate;
m) 30 parts of methionine, 60 parts of animal fat (solidified) and 10 parts of sodium stearate;
f) 30 parts of methionine, 50 parts of animal fat (cured) and 20 parts of sodium stearate.
The results of the dissolution of methionine are given in table. 11 and 12.
Example 11. a) Comparative test: 70 parts of animal fat (hardened) are melted at 80 ° C and, with stirring, suspended in the melt 30.h. methionine. The melt is dropped from the nozzle, thus obtaining the same spherical particles with a diameter of 1-2 mm;
b) from a mixture of 60 parts of animal fat (hardened) and 10 hours of sodium palmitate, a single melt is obtained by heating to 80 ° C, in which methionine is also suspended for 30 hours. Particles are obtained according to paragraph a.
Similarly, particles are obtained from:
c) 30 parts of methionine, 50 parts of animal fat (cured) and 20 hours of sodium palmitate;
d) 30 parts of methionine, 60 parts of animal fat (solidified) and 10 hours of potassium palmitate;
e) 30 parts of methionine, 50 parts of the animal} jpipa (cured) and 20 parts of potassium palmitate;
f) 30 parts of methionine, 60 parts of animal fat (cured) and 10 hours of sodium stearate;
g) 30 parts of methionine, 50 parts of animal fat (cured) and 20 parts of sodium stearate;
h) 30 parts of methionine, 60 parts of animal fat (cured) and 10 parts of potassium stearate;
i) 30 parts of methionine, 30 parts of animal fat (solidified) and 20 parts of CTeapal-a potassium,
The results of the dissolution of methionine are given in Table. 13 and 14.
Example 12. a) (Comparative test). 70 parts of palmitic acid are melted at 80 ° C and suspended in the melt with stirring 30 parts of methionine. The melt produces a drop nozzle, and form a uniform spherical particles with a diameter of 1-2 mm;
b) from a mixture containing 60 parts of pamitic acid and 10 hours of sodium palmitate, a homogeneous melt is formed by heating to 80 ° C, in which 30 parts of methionine are also suspended.
In a similar way, particles are obtained from: c) 30 parts of methionine, 55 parts of palm palmic acid and 15 hours of sodium palmitate; d) 30 parts of methionine, LOh, palmitic acid and 20 parts of palmitic and sodium; e) 30 parts of methionine, 50 hours, palm tinic acid, 20 hours potassium palmitate; e) 30 parts of methionine, A5 parts of palmitic acid and 25 hours of sodium palmitate; g) 30 hours of methionine, 35 hours, palmitic acid, and 35 hours of sodium palm. The check of additives is carried out by the method described in example 1, the results of KOTopenl are given in table. Example 13 An additive obtained according to example 1, in an amount of 1 g and consisting of 30 parts of methion, 50 parts of stearic acid and 20 sodium stearate, was tested with a dairy cow in which the rennet and the small intestine was reusable fistula was promptly introduced. Rennet juice was continuously collected using a cannula. After sampling for analysis, rennet juice was reintroduced into the small intestine through the fistula. The cow was kept in a special chamber for measuring metabolism. Initially, methionine flux to rennet was measured at the time when the main ration was given, consisting of hay and combi feed. Then, a basic ration-like diet was added with the addition of the product described in Example 1, and the methionine flux was also measured. The cow received 9.0 kg of feed per day and 5.5 kg of hay, depending on the yield and feed consumption. The composition of feed is as follows, May.%: Corn gluten Crushed dried fodder beet Citrus dried pulp Coconut meal Schrox flax seed Soybean meal Soybean oil Molasses SANROD-N O Mixture of mineral 2.0 substances 3110 The content, by weight, is analyzed by wt. Cheese: protein 14.6, methionine 0.204. The feed was given in granular form. An additive containing methioin was mixed with flour-like feed and fed separately. Measured injected dose of methionine in rennet (g / 24 h) and derived methionine in faeces x (g / 24 h). During the control period (the basic ration without the addition of methionine contained in the granules, the absorption of methionine from the main one was 37.5 g / 24 h. In the rennet, a transition of 32.02 g of methionine / 24 h was measured in accordance with 85.3% of the methionine bound to the protein, During the test period (the main ration with the addition of methionine contained in the granules), the absorption of methionine from the basic ration is 36.1 g / 24 h, and the absorption of the methionine contained in the granules is 28.7 G // 4 h. protein bound methionine to take into account the same level of chipping and formation in the rumen, as in the control period (85.3%), then the dose of methionine entering the rennet from the main diet will be max. 30.7 g / 24 h, as well as max. 28.7 g / 24 h from contained in the granules of methionine, that is, in general, 59.5 g of methionine 24 hours. The measurement gives 39.5 g of methionine / 24 hours. From this it follows that the protective part for the methionine contained in the granules is 31%. In the control period (the main ration without adding methionine contained in the granules) together with the faeces, 11.0 g of methionine was crushed 24 hours. In a comparative test (the basic diet with the addition of the methionine contained in the granules) with the feces released 10.4 g methionine. The results of the experiments show that the proposed composition of the additive provides the best absorption in the intestinal tract of the animal biologically active substances, as shown by the example of methiopin.
Table 1
Table 4
Experience to compare
Experience D / 1I comparison
Experience to compare
Experience to compare
Table 5
Table 6
Table 7
Experience to compare
Comparative test.
Table
Table 9
Comparative test.
Spreadsheets
eleven
Table 12
Table 13
nineteen
1099831
20
Il table

权利要求:
Claims (1)
[1]
ROOM ANIMAL FEED ADDITIVE containing a biologically active substance selected from the group consisting of lysine hydrochloride, nicotinic acid amide, methionine or a mixture thereof with> feathers, and a protective coating for the biologically active substance selected from the group consisting of sodium or potassium salt of stearic or palmitic acid, which is characterized in that, in order to improve its absorption and digestibility, the protective coating of the additive additionally contains stearic or palmitic acid or hardened vegetable oil or animal fat in the following ratio, wt.%: A biologically active substance selected from the group consisting of lysine hydrochloride, nicotinic acid amide, methionine or a mixture thereof with feather flour 30-50
Sodium or potassium salt of stearic or palmitic acid 10-35 Stearic or palmitic acid or hardened vegetable oil or animal fat 30-60>
in the following ratio of components, wt.%:
Biologically active

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法律状态:

优先权:

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